Nephropathy associated with sickle cell anemia: An autologous immune complex nephritis: I. Studies on nature of glomerular-bound antibody and antigen …

J Strauss, V Pardo, MN Koss, W Griswold… - The American journal of …, 1975 - Elsevier
The nature of the glomerular-bound antibody and the putative antigen was investigated in
one of the patients with sickle cell disease and immune deposit membranoproliferative
glomerulonephritis by immunohistologic and glomerular antibody elution. Renal proximal
tubular epithelial antigen was localized in association with immunoglobulins G (IgG), M
(IgM), Clq fraction of the first component of complement (Clq) and the third component of
complement (C 3) in a granular pattern along the glomerular basement membrane of the …