Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in …
DE Sleat, I Sohar, H Lackland, J Majercak… - Journal of Biological …, 1996 - ASBMB
Mannose 6-phosphate (Man-6-P) is a posttranslational carbohydrate modification typical of
newly synthesized acid hydrolases that signals targeting from the Golgi apparatus to the
lysosome via Man-6-P receptors (MPRs). Using iodinated cation independent MPR as a
probe in a Western blot assay, we surveyed levels of Man-6-P glycoproteins in a number of
different rat tissues. Considerable variation was observed with respect to total amounts and
types of Man-6-P glycoproteins in the different tissues. Brain contained 2-8-fold more Man-6 …
newly synthesized acid hydrolases that signals targeting from the Golgi apparatus to the
lysosome via Man-6-P receptors (MPRs). Using iodinated cation independent MPR as a
probe in a Western blot assay, we surveyed levels of Man-6-P glycoproteins in a number of
different rat tissues. Considerable variation was observed with respect to total amounts and
types of Man-6-P glycoproteins in the different tissues. Brain contained 2-8-fold more Man-6 …
