Regulation of Piezo2 mechanotransduction by static plasma membrane tension in primary afferent neurons
Z Jia, R Ikeda, J Ling, V Viatchenko-Karpinski… - Journal of Biological …, 2016 - ASBMB
The Piezo2 channel is a newly identified mammalian mechanical transducer that confers
rapidly adapting mechanically activated (RA-MA) currents in primary afferent neurons. The
Piezo2 channels sense rapid membrane displacement, but it is not clear whether they are
sensitive to osmotic swelling, which slowly increases static plasma membrane tension
(SPMT). Here, we show that SPMT exerts a profound impact on the mechanical sensitivity of
RA-MA channels in primary afferent neurons. RA-MA currents are greatly enhanced, and the …
rapidly adapting mechanically activated (RA-MA) currents in primary afferent neurons. The
Piezo2 channels sense rapid membrane displacement, but it is not clear whether they are
sensitive to osmotic swelling, which slowly increases static plasma membrane tension
(SPMT). Here, we show that SPMT exerts a profound impact on the mechanical sensitivity of
RA-MA channels in primary afferent neurons. RA-MA currents are greatly enhanced, and the …
