Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection
R Zangerle, B Widner, G Quirchmair, G Neurauter… - Clinical …, 2002 - Elsevier
Antiretroviral therapy (ART) has a significant impact on HIV-1 RNA levels, the CD4 cell
count, and immune activation. We examined whether these changes are associated with a
change in the rate of tryptophan degradation (expressed as the kynurenine to tryptophan
ratio, kyn/trp) as an estimate for the activity of interferon-γ inducible enzyme indoleamine (2,
3)-dioxygenase (IDO). Plasma levels of tryptophan, kynurenine, and neopterin were
measured pretherapy and 6 months postinitiation of therapy in 45 patients with HIV-1 RNA …
count, and immune activation. We examined whether these changes are associated with a
change in the rate of tryptophan degradation (expressed as the kynurenine to tryptophan
ratio, kyn/trp) as an estimate for the activity of interferon-γ inducible enzyme indoleamine (2,
3)-dioxygenase (IDO). Plasma levels of tryptophan, kynurenine, and neopterin were
measured pretherapy and 6 months postinitiation of therapy in 45 patients with HIV-1 RNA …
