Nasal potential difference measurements to assess CFTR ion channel activity
SM Rowe, JP Clancy, M Wilschanski - … Volume I: Approaches to Study and …, 2011 - Springer
SM Rowe, JP Clancy, M Wilschanski
Cystic Fibrosis: Diagnosis and Protocols, Volume I: Approaches to Study and …, 2011•SpringerThe Nasal potential difference measurement is used to measure the voltage across the
nasal epithelium, which results from transepithelial ion transport and reflects in part CFTR
function. The electrophysiologic abnormality in cystic fibrosis was first described 30 years
ago and correlates with features of the CF phenotype. NPD measurement is an important in
vivo research and diagnostic tool, and is used to assess the efficacy of new treatments such
as gene therapy and ion transport modulators. This chapter will elaborate on the …
nasal epithelium, which results from transepithelial ion transport and reflects in part CFTR
function. The electrophysiologic abnormality in cystic fibrosis was first described 30 years
ago and correlates with features of the CF phenotype. NPD measurement is an important in
vivo research and diagnostic tool, and is used to assess the efficacy of new treatments such
as gene therapy and ion transport modulators. This chapter will elaborate on the …
Abstract
The Nasal potential difference measurement is used to measure the voltage across the nasal epithelium, which results from transepithelial ion transport and reflects in part CFTR function. The electrophysiologic abnormality in cystic fibrosis was first described 30 years ago and correlates with features of the CF phenotype. NPD measurement is an important in vivo research and diagnostic tool, and is used to assess the efficacy of new treatments such as gene therapy and ion transport modulators. This chapter will elaborate on the electrophysiological principles behind the test, the equipment required, the methods, and the analysis of the data.
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