Evaluation of the inhibitory effects of human serum components on bactericidal activity of human beta defensin 3
G Maisetta, M Di Luca, S Esin, W Florio… - Peptides, 2008 - Elsevier
Naturally occurring cationic antimicrobial peptides (CAPs) are an essential component of the
innate immune system of multicellular organisms. At concentrations generally higher than
those found in vivo, most CAPs exhibit strong antibacterial properties in vitro, but their
activity may be inhibited by body fluids, a fact that could limit their future use as antimicrobial
and/or immunomodulatory agents. In the present study, we evaluated the effects of human
serum components on bactericidal activity of the human β-defensin 3 (hBD-3), a CAP …
innate immune system of multicellular organisms. At concentrations generally higher than
those found in vivo, most CAPs exhibit strong antibacterial properties in vitro, but their
activity may be inhibited by body fluids, a fact that could limit their future use as antimicrobial
and/or immunomodulatory agents. In the present study, we evaluated the effects of human
serum components on bactericidal activity of the human β-defensin 3 (hBD-3), a CAP …