Sirolimus produced S-shaped effect on adult polycystic kidneys after 2-year treatment
A Soliman, S Zamil, A Lotfy, E Ismail - Transplantation proceedings, 2012 - Elsevier
This double-blind trial followed 16 patients with autosomal dominant polycystic kidney
disease (ADPKD) who received telmisartan or sirolimus plus telmisartan for 24 months. The
6-month pilot study showed a promising effect of sirolimus. The primary metric of this 2-year
study was the change in total kidney volume at 12 and 24 months, as measured on magnetic
resonance imaging. Secondary outcome was changes in renal function from the baseline at
months 12 and 24. Among patients receiving sirolimus, the mean total kidney volume …
disease (ADPKD) who received telmisartan or sirolimus plus telmisartan for 24 months. The
6-month pilot study showed a promising effect of sirolimus. The primary metric of this 2-year
study was the change in total kidney volume at 12 and 24 months, as measured on magnetic
resonance imaging. Secondary outcome was changes in renal function from the baseline at
months 12 and 24. Among patients receiving sirolimus, the mean total kidney volume …
