Synthesis and degradation pathways, functions, and pathology of ceramides and epidermal acylceramides
A Kihara - Progress in lipid research, 2016 - Elsevier
Ceramide (Cer) is a structural backbone of sphingolipids and is composed of a long-chain
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length,
hydroxylation status, and/or double bond number of either of their hydrophobic chains, has
been reported. Ceramide is produced by Cer synthases. Mammals have six Cer synthases
(CERS1–6), each of which exhibits characteristic substrate specificity toward acyl-CoAs with
different chain-lengths. Knockout mice for each Cer synthase show corresponding, isozyme …
base and a fatty acid. Existence of a variety of Cer species, which differ in chain-length,
hydroxylation status, and/or double bond number of either of their hydrophobic chains, has
been reported. Ceramide is produced by Cer synthases. Mammals have six Cer synthases
(CERS1–6), each of which exhibits characteristic substrate specificity toward acyl-CoAs with
different chain-lengths. Knockout mice for each Cer synthase show corresponding, isozyme …
