Clinical phenotypes and endophenotypes of atopic dermatitis: where are we, and where should we go?
T Bieber, MD Angelo, CA Akdis… - Journal of Allergy and …, 2017 - Elsevier
Atopic dermatitis (AD) is a paradigmatic chronic inflammatory skin disease characterized by
a complex pathophysiology and a wide spectrum of the clinical phenotype. Despite this high
degree of heterogeneity, AD is still considered a single disease and usually treated
according to the “one-size-fits-all” approach. Thus more tailored prevention and therapeutic
strategies are still lacking. As for other disciplines, such as oncology or rheumatology, we
have to approach AD in a more differentiated way (ie, to dissect and stratify the complex …
a complex pathophysiology and a wide spectrum of the clinical phenotype. Despite this high
degree of heterogeneity, AD is still considered a single disease and usually treated
according to the “one-size-fits-all” approach. Thus more tailored prevention and therapeutic
strategies are still lacking. As for other disciplines, such as oncology or rheumatology, we
have to approach AD in a more differentiated way (ie, to dissect and stratify the complex …
