[HTML][HTML] Sorting nexin 1 loss results in D5 dopamine receptor dysfunction in human renal proximal tubule cells and hypertension in mice
MV Van Anthony, JE Jones, I Armando, LD Asico… - Journal of Biological …, 2013 - ASBMB
The peripheral dopaminergic system plays a crucial role in blood pressure regulation
through its actions on renal hemodynamics and epithelial ion transport. The dopamine D5
receptor (D 5 R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval
from the trans-Golgi network. In this report, we elucidated the spatial, temporal, and
functional significance of this interaction in human renal proximal tubule cells and HEK293
cells stably expressing human D 5 R and in mice. Silencing of SNX1 expression via RNAi …
through its actions on renal hemodynamics and epithelial ion transport. The dopamine D5
receptor (D 5 R) interacts with sorting nexin 1 (SNX1), a protein involved in receptor retrieval
from the trans-Golgi network. In this report, we elucidated the spatial, temporal, and
functional significance of this interaction in human renal proximal tubule cells and HEK293
cells stably expressing human D 5 R and in mice. Silencing of SNX1 expression via RNAi …