Dopamine suppresses IL-12 p40 production by lipopolysaccharide-stimulated macrophages via a β-adrenoceptor-mediated mechanism
In this study, we examined the effect of dopamine on the production of IL-12 p40 by
lipopolysaccharide (LPS)-stimulated J774. 1 macrophages and mouse peritoneal
macrophages. Treatment of J774. 1 cells with dopamine (0.01–100 μM) decreased the
release of IL-12 p40, in a concentration-dependent manner. The attenuating effect of
dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine
decreased mRNA accumulation of IL-12 p40. The inhibitory effect of dopamine on IL-12 p40 …
lipopolysaccharide (LPS)-stimulated J774. 1 macrophages and mouse peritoneal
macrophages. Treatment of J774. 1 cells with dopamine (0.01–100 μM) decreased the
release of IL-12 p40, in a concentration-dependent manner. The attenuating effect of
dopamine on IL-12 p40 production appeared to be pretranslational, because dopamine
decreased mRNA accumulation of IL-12 p40. The inhibitory effect of dopamine on IL-12 p40 …