Are snoRNAs and snoRNA host genes new players in cancer?
GT Williams, F Farzaneh - Nature reviews cancer, 2012 - nature.com
GT Williams, F Farzaneh
Nature reviews cancer, 2012•nature.comSmall nucleolar RNAs (snoRNAs) have long been considered important but unglamorous
elements in the production of the protein synthesis machinery of the cell. Recently, however,
several independent lines of evidence have indicated that these non-coding RNAs might
have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently
contribute to oncogenesis in previously unsuspected ways.
elements in the production of the protein synthesis machinery of the cell. Recently, however,
several independent lines of evidence have indicated that these non-coding RNAs might
have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently
contribute to oncogenesis in previously unsuspected ways.
Abstract
Small nucleolar RNAs (snoRNAs) have long been considered important but unglamorous elements in the production of the protein synthesis machinery of the cell. Recently, however, several independent lines of evidence have indicated that these non-coding RNAs might have crucial roles in controlling cell behaviour, and snoRNA dysfunction could consequently contribute to oncogenesis in previously unsuspected ways.
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