[PDF][PDF] Costimulation engages the gear in driving CARs
H Abken - Immunity, 2016 - cell.com
H Abken
Immunity, 2016•cell.comIn this issue of Immunity, Kawalekar et al.(2016) find that costimulation by a chimeric antigen
receptor (CAR) can control T cell metabolism and balance the response toward long-lived
memory or short-lived effector cells. The results provide a rationale of how to tune cancer
immunotherapy more effectively in a hostile tumor environment.
receptor (CAR) can control T cell metabolism and balance the response toward long-lived
memory or short-lived effector cells. The results provide a rationale of how to tune cancer
immunotherapy more effectively in a hostile tumor environment.
In this issue of Immunity, Kawalekar et al. (2016) find that costimulation by a chimeric antigen receptor (CAR) can control T cell metabolism and balance the response toward long-lived memory or short-lived effector cells. The results provide a rationale of how to tune cancer immunotherapy more effectively in a hostile tumor environment.
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