[HTML][HTML] TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
E Omori, K Matsumoto, H Sanjo, S Sato, S Akira… - Journal of Biological …, 2006 - ASBMB
Transforming growth factor β-activated kinase 1 (TAK1) functions downstream of
inflammatory cytokines to activate c-Jun N-terminal kinase (JNK) as well as NF-κB in several
cell types. However, the functional role of TAK1 in an in vivo setting has not been
determined. Here we have demonstrated that TAK1 is the major regulator of skin
inflammation as well as keratinocyte death in vivo. Epidermal-specific deletion of TAK1
causes a severe inflammatory skin condition by postnatal day 6-8. The mutant skin also …
inflammatory cytokines to activate c-Jun N-terminal kinase (JNK) as well as NF-κB in several
cell types. However, the functional role of TAK1 in an in vivo setting has not been
determined. Here we have demonstrated that TAK1 is the major regulator of skin
inflammation as well as keratinocyte death in vivo. Epidermal-specific deletion of TAK1
causes a severe inflammatory skin condition by postnatal day 6-8. The mutant skin also …