KATP channels in mesenchymal stromal stem cells: strong up-regulation of Kir6. 2 subunits upon osteogenic differentiation
A Diehlmann, S Bork, R Saffrich, RW Veh, W Wagner… - Tissue and Cell, 2011 - Elsevier
The promising use of mesenchymal stromal cells (MSC) in regenerative technologies
accounts for necessity of detailed study of their physiology. Proliferation and differentiation of
multipotent cells often involve changes in their metabolic state. In the present study, we
analyzed the expression of ATP-sensitive potassium (KATP) channels in MSC and upon in
vitro differentiation. KATP channels are present in many cells and regulate a variety of
cellular functions by coupling cell metabolism with membrane potential. Kir6. 1, Kir6. 2 and …
accounts for necessity of detailed study of their physiology. Proliferation and differentiation of
multipotent cells often involve changes in their metabolic state. In the present study, we
analyzed the expression of ATP-sensitive potassium (KATP) channels in MSC and upon in
vitro differentiation. KATP channels are present in many cells and regulate a variety of
cellular functions by coupling cell metabolism with membrane potential. Kir6. 1, Kir6. 2 and …
