Organization of the mouse and human DC network
A Schlitzer, F Ginhoux - Current opinion in immunology, 2014 - Elsevier
Current opinion in immunology, 2014•Elsevier
Highlights•We review the organization and the relationships of mouse and human DC
networks.•Mouse and human DC networks are similarly organized.•Mouse CD8α+/CD103+
DCs are related to human CD141+ DCs and excel at crosspresentation.•Mouse CD11b+
DCs are related to human CD1c+ DCs, exhibiting Th17 polarizing properties.•Mouse and
human inflammatory DCs exert context-dependent immunity.Dendritic cells (DCs) are the
most potent antigen sensing and presenting cells in the body and are able to both initiate …
networks.•Mouse and human DC networks are similarly organized.•Mouse CD8α+/CD103+
DCs are related to human CD141+ DCs and excel at crosspresentation.•Mouse CD11b+
DCs are related to human CD1c+ DCs, exhibiting Th17 polarizing properties.•Mouse and
human inflammatory DCs exert context-dependent immunity.Dendritic cells (DCs) are the
most potent antigen sensing and presenting cells in the body and are able to both initiate …
Highlights
- We review the organization and the relationships of mouse and human DC networks.
- Mouse and human DC networks are similarly organized.
- Mouse CD8α+/CD103+ DCs are related to human CD141+ DCs and excel at crosspresentation.
- Mouse CD11b+ DCs are related to human CD1c+ DCs, exhibiting Th17 polarizing properties.
- Mouse and human inflammatory DCs exert context-dependent immunity.
Dendritic cells (DCs) are the most potent antigen sensing and presenting cells in the body and are able to both initiate and fine-tune complex immune responses on a multitude of levels. In this review, we outline recent advances in our understanding of the organization of the DC network in mice and humans, the functional specialization of the DC subsets that compose these networks, and how this has enabled us to begin to elucidate cross-species parallels. Understanding the inter-relationships between DC populations in both man and mouse will ultimately allow us to exploit our knowledge of DC biology for effective therapeutic strategies.
Elsevier