[HTML][HTML] Nephron number in patients with primary hypertension
G Keller, G Zimmer, G Mall, E Ritz… - New England Journal of …, 2003 - Mass Medical Soc
G Keller, G Zimmer, G Mall, E Ritz, K Amann
New England Journal of Medicine, 2003•Mass Medical SocBackground A diminished number of nephrons has been proposed as one of the factors
contributing to the development of primary hypertension. Methods To test this hypothesis, we
used a three-dimensional stereologic method to compare the number and volume of
glomeruli in 10 middle-aged white patients (age range, 35 to 59 years) with a history of
primary hypertension or left ventricular hypertrophy (or both) and renal arteriolar lesions with
the number and volume in 10 normotensive subjects matched for sex, age, height, and …
contributing to the development of primary hypertension. Methods To test this hypothesis, we
used a three-dimensional stereologic method to compare the number and volume of
glomeruli in 10 middle-aged white patients (age range, 35 to 59 years) with a history of
primary hypertension or left ventricular hypertrophy (or both) and renal arteriolar lesions with
the number and volume in 10 normotensive subjects matched for sex, age, height, and …
Background
A diminished number of nephrons has been proposed as one of the factors contributing to the development of primary hypertension.
Methods
To test this hypothesis, we used a three-dimensional stereologic method to compare the number and volume of glomeruli in 10 middle-aged white patients (age range, 35 to 59 years) with a history of primary hypertension or left ventricular hypertrophy (or both) and renal arteriolar lesions with the number and volume in 10 normotensive subjects matched for sex, age, height, and weight. All 20 subjects had died in accidents.
Results
Patients with hypertension had significantly fewer glomeruli per kidney than matched normotensive controls (median, 702,379 vs. 1,429,200). Patients with hypertension also had a significantly greater glomerular volume than did the controls (median, 6.50×10–3 mm3 vs. 2.79×10–3 mm3; P<0.001) but very few obsolescent glomeruli.
Conclusions
The data support the hypothesis that the number of nephrons is reduced in white patients with primary hypertension.
The New England Journal Of Medicine