Msx2 is required for vascular smooth muscle cells osteoblastic differentiation but not calcification in insulin-resistant ob/ob mice
Background and aims Obesity and diabetes potentiate vascular calcification by increasing
vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor
Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to
induce VSMC osteogenic phenotype transition and calcification is poorly understood in
diabetes. We aimed to investigate mechanisms underlying Bmp-2-driven VSMC osteogenic
differentiation and calcification in leptin-deficient ob/ob mice. Methods We incubated VSMC …
vascular smooth muscle cells osteoblastic differentiation mediated by the transcription factor
Msx2 and bone morphogenetic protein-2 signaling. However, Bmp-2/Msx2 crosstalk to
induce VSMC osteogenic phenotype transition and calcification is poorly understood in
diabetes. We aimed to investigate mechanisms underlying Bmp-2-driven VSMC osteogenic
differentiation and calcification in leptin-deficient ob/ob mice. Methods We incubated VSMC …
