Role of homocysteine in aortic calcification and osteogenic cell differentiation

A Van Campenhout, CS Moran, A Parr, P Clancy… - Atherosclerosis, 2009 - Elsevier
BACKGROUND: The role of homocysteine in atherosclerosis is unclear. We examined the
relationship between plasma homocysteine and infrarenal aortic calcification, the presence
of homocysteine in human atheroma and the influence of homocysteine on osteogenic
differentiation in vitro. METHODS AND RESULTS: In 194 patients with symptomatic
peripheral artery disease or abdominal aortic aneurysm, fasting plasma total homocysteine
was independently associated with the severity of infrarenal aortic calcification measured by …