Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated …
T Nakajima, K Kitagawa, T Ohhata, S Sakai… - Journal of Biological …, 2015 - ASBMB
A GATA family transcription factor, GATA-binding protein 2 (GATA2), participates in cell
growth and differentiation of various cells, such as hematopoietic stem cells. Although its
expression level is controlled by transcriptional induction and proteolytic degradation, the
responsible E3 ligase has not been identified. Here, we demonstrate that F-box/WD repeat-
containing protein 7 (Fbw7/Fbxw7), a component of Skp1, Cullin 1, F-box-containing
complex (SCF)-type E3 ligase, is an E3 ligase for GATA2. GATA2 contains a cell division …
growth and differentiation of various cells, such as hematopoietic stem cells. Although its
expression level is controlled by transcriptional induction and proteolytic degradation, the
responsible E3 ligase has not been identified. Here, we demonstrate that F-box/WD repeat-
containing protein 7 (Fbw7/Fbxw7), a component of Skp1, Cullin 1, F-box-containing
complex (SCF)-type E3 ligase, is an E3 ligase for GATA2. GATA2 contains a cell division …
