[HTML][HTML] Loss of cyclin-dependent kinase 1 impairs bone formation, but does not affect the bone-anabolic effects of parathyroid hormone
A Takahashi, M Mulati, M Saito, H Numata… - Journal of Biological …, 2018 - ASBMB
Bone mass is maintained by a balance between osteoblast-mediated bone formation and
osteoclast-mediated bone resorption. Although recent genetic studies have uncovered
various mechanisms that regulate osteoblast differentiation, the molecular basis of
osteoblast proliferation remains unclear. Here, using an osteoblast-specific loss-of-function
mouse model, we demonstrate that cyclin-dependent kinase 1 (Cdk1) regulates osteoblast
proliferation and differentiation. Quantitative RT-PCR analyses revealed that Cdk1 is highly …
osteoclast-mediated bone resorption. Although recent genetic studies have uncovered
various mechanisms that regulate osteoblast differentiation, the molecular basis of
osteoblast proliferation remains unclear. Here, using an osteoblast-specific loss-of-function
mouse model, we demonstrate that cyclin-dependent kinase 1 (Cdk1) regulates osteoblast
proliferation and differentiation. Quantitative RT-PCR analyses revealed that Cdk1 is highly …
