[HTML][HTML] MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1
Ethanol-mediated inhibition of hepatic sirtuin 1 (SIRT1) plays a crucial role in the
pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying
mechanisms of this inhibition by identifying a new hepatic target of ethanol action, microRNA-
217 (miR-217). The role of miR-217 in the regulation of the effects of ethanol was
investigated in cultured mouse AML-12 hepatocytes and in the livers of chronically ethanol-
fed mice. In AML-12 hepatocytes and in mouse livers, chronic ethanol exposure drastically …
pathogenesis of alcoholic fatty liver disease. Here, we investigated the underlying
mechanisms of this inhibition by identifying a new hepatic target of ethanol action, microRNA-
217 (miR-217). The role of miR-217 in the regulation of the effects of ethanol was
investigated in cultured mouse AML-12 hepatocytes and in the livers of chronically ethanol-
fed mice. In AML-12 hepatocytes and in mouse livers, chronic ethanol exposure drastically …
