[HTML][HTML] MicroRNA cargo of extracellular vesicles from alcohol-exposed monocytes signals naive monocytes to differentiate into M2 macrophages
B Saha, F Momen-Heravi, K Kodys, G Szabo - Journal of Biological …, 2016 - ASBMB
Membrane-coated extracellular vesicles (EVs) released by cells can serve as vehicles for
delivery of biological materials and signals. Recently, we demonstrated that alcohol-treated
hepatocytes cross-talk with immune cells via exosomes containing microRNA (miRNAs).
Here, we hypothesized that alcohol-exposed monocytes can communicate with naive
monocytes via EVs. We observed increased numbers of EVs, mostly exosomes, secreted by
primary human monocytes and THP-1 monocytic cells in the presence of alcohol in a …
delivery of biological materials and signals. Recently, we demonstrated that alcohol-treated
hepatocytes cross-talk with immune cells via exosomes containing microRNA (miRNAs).
Here, we hypothesized that alcohol-exposed monocytes can communicate with naive
monocytes via EVs. We observed increased numbers of EVs, mostly exosomes, secreted by
primary human monocytes and THP-1 monocytic cells in the presence of alcohol in a …
