[HTML][HTML] Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer
Z Qu, J Fu, P Yan, J Hu, SY Cheng, G Xiao - Journal of biological chemistry, 2010 - ASBMB
The NF-κB transcription factor plays a pivotal role in breast cancer progression and therapy
resistance. However, the mechanisms by which the tightly regulated NF-κB becomes
constitutively activated during breast cancer pathogenesis remain obscure. Here, we report
that PDZ-LIM domain-containing protein 2 (PDLIM2), an essential terminator of NF-κB
activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative
breast cancer cells, suggesting one important mechanism for the constitutive activation of NF …
resistance. However, the mechanisms by which the tightly regulated NF-κB becomes
constitutively activated during breast cancer pathogenesis remain obscure. Here, we report
that PDZ-LIM domain-containing protein 2 (PDLIM2), an essential terminator of NF-κB
activation, is repressed in both estrogen receptor-positive and estrogen receptor-negative
breast cancer cells, suggesting one important mechanism for the constitutive activation of NF …
