[HTML][HTML] Regulation of NF-κB2 p100 processing by its cis-acting domain
G Qing, Z Qu, G Xiao - Journal of Biological Chemistry, 2005 - ASBMB
Processing of NF-κB2 precursor protein p100 to generate p52 is tightly regulated. However,
this proteolytic event could be actively induced by the NF-κB-inducing kinase and the human
T-cell leukemia virus-encoded oncoprotein Tax or be constitutively turned on due to the loss
of the C-terminal portion of p100. Whereas NF-κB-inducing kinase-mediated p100
processing requires β-transducin repeat-containing protein, constitutive processing of p100
is independent of this protein. On the other hand, Tax-induced processing of p100 appears …
this proteolytic event could be actively induced by the NF-κB-inducing kinase and the human
T-cell leukemia virus-encoded oncoprotein Tax or be constitutively turned on due to the loss
of the C-terminal portion of p100. Whereas NF-κB-inducing kinase-mediated p100
processing requires β-transducin repeat-containing protein, constitutive processing of p100
is independent of this protein. On the other hand, Tax-induced processing of p100 appears …