[HTML][HTML] Transcriptional upregulation of HIF-1α by NF-κB/p65 and its associations with β-catenin/p300 complexes in endometrial carcinoma cells
T Yoshida, M Hashimura, T Mastumoto, Y Tazo… - Laboratory …, 2013 - Elsevier
The hypoxia-inducible factor (HIF)-1α, which has a major role in cell adaptation to hypoxia,
is mainly regulated at post-translational levels. Recently, HIF-1α mRNA was also shown to
be upregulated by several signal pathways under normoxic conditions. Here we focused on
relationships of HIF-1α with NF-κB and β-catenin signaling in endometrial carcinomas (Em
Cas). Long-term exposure of Ishikawa cells to cobalt chloride (CoCl 2), which is known to
mimic the effect of hypoxia, caused a decrease in the growth, along with increased HIF-1α …
is mainly regulated at post-translational levels. Recently, HIF-1α mRNA was also shown to
be upregulated by several signal pathways under normoxic conditions. Here we focused on
relationships of HIF-1α with NF-κB and β-catenin signaling in endometrial carcinomas (Em
Cas). Long-term exposure of Ishikawa cells to cobalt chloride (CoCl 2), which is known to
mimic the effect of hypoxia, caused a decrease in the growth, along with increased HIF-1α …