Alternative pathways of NF-κB activation: a double-edged sword in health and disease
G Xiao, AB Rabson, W Young, G Qing, Z Qu - Cytokine & growth factor …, 2006 - Elsevier
While the classical pathway of NF-κB activation plays critical roles in a wide range of
biological processes, the more recently described “non-canonical” NF-κB pathway has
important but more restricted roles in both normal and pathological processes. The non-
canonical NF-κB pathway, based on processing of the nf-κb2 gene product p100 to generate
p52, appears to be involved in B-cell maturation and lymphoid development. Deregulated
activation of this pathway has been observed in a variety of malignant and autoimmune …
biological processes, the more recently described “non-canonical” NF-κB pathway has
important but more restricted roles in both normal and pathological processes. The non-
canonical NF-κB pathway, based on processing of the nf-κb2 gene product p100 to generate
p52, appears to be involved in B-cell maturation and lymphoid development. Deregulated
activation of this pathway has been observed in a variety of malignant and autoimmune …