The spatial-temporal reactive changes of compressed optic nerve in a clinically relevant rabbit model of persistent compressive optic nerve axonopathy
E Wu, XH Jiang, J Sun, B Xu, W Li, Q Liao… - Experimental Eye …, 2023 - Elsevier
The optic nerve (ON) can get compressed in different diseases. However, the pathological
and functional changes occurring in the compressed ON over time under constant
compression are still unclear. In the present study, we implanted an artificial tube around the
optic nerve of a rabbit to primarily create a clinically relevant persistent compressive optic
nerve axonopathy (PCOA). Due to the protuberance on the inner ring of the tube, steady and
persistent compressions were maintained. In this model, we investigated the thickness of …
and functional changes occurring in the compressed ON over time under constant
compression are still unclear. In the present study, we implanted an artificial tube around the
optic nerve of a rabbit to primarily create a clinically relevant persistent compressive optic
nerve axonopathy (PCOA). Due to the protuberance on the inner ring of the tube, steady and
persistent compressions were maintained. In this model, we investigated the thickness of …