In vivo evaluation of retinal ganglion cells and optic nerve's integrity in large animals by multi-modality analysis
Y Zhang, S Zhang, Y Xia, Y Ji, W Jiang, M Li… - Experimental Eye …, 2020 - Elsevier
Large animal models of optic nerve injury are essential for translating novel findings into
effective therapies due to their similarity to humans in many respects. However, most current
tests evaluating the integrity of retinal ganglion cells (RGCs) and optic nerve (ON) are based
on rodent animal models. We aimed to evaluate and optimize the in vivo methods to assess
RGCs and ON's function and structure in large animals in terms of reproducibility, simplicity
and sensitivity. Both goats and rhesus macaques were employed in this study. By using …
effective therapies due to their similarity to humans in many respects. However, most current
tests evaluating the integrity of retinal ganglion cells (RGCs) and optic nerve (ON) are based
on rodent animal models. We aimed to evaluate and optimize the in vivo methods to assess
RGCs and ON's function and structure in large animals in terms of reproducibility, simplicity
and sensitivity. Both goats and rhesus macaques were employed in this study. By using …
