The transcription factor c-jun is activated in retinal ganglion cells in experimental rat glaucoma
H Levkovitch-Verbin, HA Quigley, KRG Martin… - Experimental eye …, 2005 - Elsevier
This study investigates the role of the MAP kinase pathway including c-jun, ATF-2 and JNK
in glaucomatous eyes of rats and in optic nerve transection. Glaucoma was induced in one
eye of 51 adult Wistar rats by laser treatment to the trabecular meshwork. Eighteen further
rats underwent unilateral optic nerve transection. We studied the transcription factor c-jun, its
activated form, phospho-c-jun, the transcription factor p-ATF-2, and the enzyme JNK by
immunohistochemistry. The activation of pc-jun was also investigated using western blot …
in glaucomatous eyes of rats and in optic nerve transection. Glaucoma was induced in one
eye of 51 adult Wistar rats by laser treatment to the trabecular meshwork. Eighteen further
rats underwent unilateral optic nerve transection. We studied the transcription factor c-jun, its
activated form, phospho-c-jun, the transcription factor p-ATF-2, and the enzyme JNK by
immunohistochemistry. The activation of pc-jun was also investigated using western blot …