Intestinal inflammation modulates the expression of ACE2 and TMPRSS2 and potentially overlaps with the pathogenesis of SARS-CoV-2–related disease
M Suárez-Fariñas, M Tokuyama, G Wei, R Huang… - Gastroenterology, 2021 - Elsevier
Gastroenterology, 2021•Elsevier
Background and Aims The presence of gastrointestinal symptoms and high levels of viral
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) replication within enterocytes. Methods Here, in multiple, large cohorts of patients
with inflammatory bowel disease (IBD), we have studied the intersections between
Coronavirus Disease 2019 (COVID-19), intestinal inflammation, and IBD treatment. Results
A striking expression of ACE2 on the small bowel enterocyte brush border supports …
RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) replication within enterocytes. Methods Here, in multiple, large cohorts of patients
with inflammatory bowel disease (IBD), we have studied the intersections between
Coronavirus Disease 2019 (COVID-19), intestinal inflammation, and IBD treatment. Results
A striking expression of ACE2 on the small bowel enterocyte brush border supports …
Background and Aims
The presence of gastrointestinal symptoms and high levels of viral RNA in the stool suggest active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication within enterocytes.
Methods
Here, in multiple, large cohorts of patients with inflammatory bowel disease (IBD), we have studied the intersections between Coronavirus Disease 2019 (COVID-19), intestinal inflammation, and IBD treatment.
Results
A striking expression of ACE2 on the small bowel enterocyte brush border supports intestinal infectivity by SARS-CoV-2. Commonly used IBD medications, both biologic and nonbiologic, do not significantly impact ACE2 and TMPRSS2 receptor expression in the uninflamed intestines. In addition, we have defined molecular responses to COVID-19 infection that are also enriched in IBD, pointing to shared molecular networks between COVID-19 and IBD.
Conclusions
These data generate a novel appreciation of the confluence of COVID-19– and IBD-associated inflammation and provide mechanistic insights supporting further investigation of specific IBD drugs in the treatment of COVID-19. Preprint doi: https://doi.org/10.1101/2020.05.21.109124
Elsevier
