WNT5B in cellular signaling pathways
RS Perkins, S Suthon, GA Miranda-Carboni… - Seminars in Cell & …, 2022 - Elsevier
RS Perkins, S Suthon, GA Miranda-Carboni, SA Krum
Seminars in Cell & Developmental Biology, 2022•ElsevierThe Wnt signaling ligand WNT5B is implicated in various developmental pathways, both in
normal and pathological physiology. Most of the research on WNT5B has been associated
with expression analysis and disease states, leaving the signaling pathways underexplored.
Here, we review the current understandings of WNT5B's regulation of signal transduction,
from receptors to downstream mediators and transcription factors. We also describe its roles
in β-catenin-dependent and β-catenin-independent (Planar Cell Polarity and Wnt/Ca 2+) …
normal and pathological physiology. Most of the research on WNT5B has been associated
with expression analysis and disease states, leaving the signaling pathways underexplored.
Here, we review the current understandings of WNT5B's regulation of signal transduction,
from receptors to downstream mediators and transcription factors. We also describe its roles
in β-catenin-dependent and β-catenin-independent (Planar Cell Polarity and Wnt/Ca 2+) …
Abstract
The Wnt signaling ligand WNT5B is implicated in various developmental pathways, both in normal and pathological physiology. Most of the research on WNT5B has been associated with expression analysis and disease states, leaving the signaling pathways underexplored. Here, we review the current understandings of WNT5B’s regulation of signal transduction, from receptors to downstream mediators and transcription factors. We also describe its roles in β-catenin-dependent and β-catenin-independent (Planar Cell Polarity and Wnt/Ca2+) Wnt signaling.
Elsevier