[HTML][HTML] Maresin 1 attenuates mitochondrial dysfunction through the ALX/cAMP/ROS pathway in the cecal ligation and puncture mouse model and sepsis patients
J Gu, L Luo, Q Wang, S Yan, J Lin, D Li, B Cao… - Laboratory …, 2018 - Elsevier
Inflammation always accompanies infection during sepsis. Mitochondrial dysfunction and
the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in
the pathogenesis of sepsis. Maresins have protective and resolving effects in experimental
models of infection. In the present study, we investigated the effects of maresin 1 (MaR1) on
mitochondrial function in cecal ligation and puncture (CLP)-induced sepsis and sepsis
patients to identify mechanisms underlying maresin 1-mediated stimulation of ROS in …
the role of reactive oxygen species (ROS) produced by mitochondria have been proposed in
the pathogenesis of sepsis. Maresins have protective and resolving effects in experimental
models of infection. In the present study, we investigated the effects of maresin 1 (MaR1) on
mitochondrial function in cecal ligation and puncture (CLP)-induced sepsis and sepsis
patients to identify mechanisms underlying maresin 1-mediated stimulation of ROS in …
