[HTML][HTML] α-Synuclein fibrillogenesis is nucleation-dependent: implications for the pathogenesis of Parkinson′ s disease
SJ Wood, J Wypych, S Steavenson, JC Louis… - Journal of Biological …, 1999 - ASBMB
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically
characterized by the presence of intracytoplasmic Lewy bodies, the major components of
which are filaments consisting of α-synuclein. Two recently identified point mutations in α-
synuclein are the only known genetic causes of PD. α-Synuclein fibrils similar to the Lewy
body filaments can be formedin vitro, and we have shown recently that both PD-linked
mutations accelerate their formation. This study addresses the mechanism of α-synuclein …
characterized by the presence of intracytoplasmic Lewy bodies, the major components of
which are filaments consisting of α-synuclein. Two recently identified point mutations in α-
synuclein are the only known genetic causes of PD. α-Synuclein fibrils similar to the Lewy
body filaments can be formedin vitro, and we have shown recently that both PD-linked
mutations accelerate their formation. This study addresses the mechanism of α-synuclein …
