Multimodal techniques for diagnosis and prognosis of Alzheimer's disease
RJ Perrin, AM Fagan, DM Holtzman - Nature, 2009 - nature.com
RJ Perrin, AM Fagan, DM Holtzman
Nature, 2009•nature.comAlzheimer's disease affects millions of people around the world. Currently, there are no
treatments that prevent or slow the disease. Like other neurodegenerative diseases,
Alzheimer's disease is characterized by protein misfolding in the brain. This process and the
associated brain damage begin years before the substantial neurodegeneration that
accompanies dementia. Studies using new neuroimaging techniques and fluid biomarkers
suggest that Alzheimer's disease pathology can be detected preclinically. These advances …
treatments that prevent or slow the disease. Like other neurodegenerative diseases,
Alzheimer's disease is characterized by protein misfolding in the brain. This process and the
associated brain damage begin years before the substantial neurodegeneration that
accompanies dementia. Studies using new neuroimaging techniques and fluid biomarkers
suggest that Alzheimer's disease pathology can be detected preclinically. These advances …
Abstract
Alzheimer's disease affects millions of people around the world. Currently, there are no treatments that prevent or slow the disease. Like other neurodegenerative diseases, Alzheimer's disease is characterized by protein misfolding in the brain. This process and the associated brain damage begin years before the substantial neurodegeneration that accompanies dementia. Studies using new neuroimaging techniques and fluid biomarkers suggest that Alzheimer's disease pathology can be detected preclinically. These advances should allow the design of new clinical trials and early mechanism-based therapeutic intervention.
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