Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease
PN Alexandrov, A Pogue, S Bhattacharjee… - Neuroreport, 2011 - journals.lww.com
Murine transgenic models of Alzheimer's disease (Tg-AD) have been useful to analyze the
contribution of β-amyloid precursor protein (βAPP), Aβ42 peptide deposition, and the
proinflammatory mechanisms that characterize Alzheimer-type neuropathology. In this
report, we have studied the levels of βAPP, Aβ40 and Aβ42 peptide, as well as the innate
immune and inflammatory response-regulator complement factor H in the brain and retina in
four different Tg-AD models including Tg2576, PSAPP, 3xTg-AD, and 5xFAD. Aged …
contribution of β-amyloid precursor protein (βAPP), Aβ42 peptide deposition, and the
proinflammatory mechanisms that characterize Alzheimer-type neuropathology. In this
report, we have studied the levels of βAPP, Aβ40 and Aβ42 peptide, as well as the innate
immune and inflammatory response-regulator complement factor H in the brain and retina in
four different Tg-AD models including Tg2576, PSAPP, 3xTg-AD, and 5xFAD. Aged …
