Structure and function of TET enzymes
X Yin, Y Xu - DNA methyltransferases-role and function, 2016 - Springer
X Yin, Y Xu
DNA methyltransferases-role and function, 2016•SpringerMammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC).
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine
(5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized
5mC derivatives play important roles in various biological and pathological processes,
including regulation of DNA demethylation, gene transcription, embryonic development, and
oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation …
TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine
(5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized
5mC derivatives play important roles in various biological and pathological processes,
including regulation of DNA demethylation, gene transcription, embryonic development, and
oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation …
Abstract
Mammalian DNA methylation mainly occurs at the carbon-C5 position of cytosine (5mC). TET enzymes were discovered to successively oxidize 5mC to 5-hydromethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). TET enzymes and oxidized 5mC derivatives play important roles in various biological and pathological processes, including regulation of DNA demethylation, gene transcription, embryonic development, and oncogenesis. In this chapter, we will discuss the discovery of TET-mediated 5mC oxidation and the structure, function, and regulation of TET enzymes.
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