Overview of the oncogenic signaling pathways in colorectal cancer: Mechanistic insights
AA Farooqi, M De La Roche, MBA Djamgoz… - Seminars in cancer …, 2019 - Elsevier
AA Farooqi, M De La Roche, MBA Djamgoz, ZH Siddik
Seminars in cancer biology, 2019•ElsevierColorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of
spatio-temporally controlled signaling pathways play instrumental role in development and
progression of colorectal cancer. High-throughput technologies have helped to develop a
sharper and broader understanding of the wide ranging signal transduction cascades which
also contribute to development of drug resistance, loss of apoptosis and, ultimately, of …
insights gleaned from almost a quarter century of research, it is obvious that deregulation of
spatio-temporally controlled signaling pathways play instrumental role in development and
progression of colorectal cancer. High-throughput technologies have helped to develop a
sharper and broader understanding of the wide ranging signal transduction cascades which
also contribute to development of drug resistance, loss of apoptosis and, ultimately, of …
Abstract
Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on insights gleaned from almost a quarter century of research, it is obvious that deregulation of spatio-temporally controlled signaling pathways play instrumental role in development and progression of colorectal cancer. High-throughput technologies have helped to develop a sharper and broader understanding of the wide ranging signal transduction cascades which also contribute to development of drug resistance, loss of apoptosis and, ultimately, of metastasis. In this review, we have set the spotlight on role of JAK/STAT, TGF/SMAD, Notch, WNT/β-Catenin, SHH/GLI and p53 pathways in the development and progression of colorectal cancer. We have also highlighted recent reports on TRAIL-mediated pathways and molecularly distinct voltage-gated sodium channels in colorectal cancer.
Elsevier
