[HTML][HTML] Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells
A complex network of transcription factors regulates genes involved in establishing and
maintaining key biological properties of the human airway epithelium. However, detailed
knowledge of the contributing factors is incomplete. Here we characterize the role of Krüppel-
like factor 5 (KLF5), in controlling essential pathways of epithelial cell identity and function in
the human lung. RNA-seq following siRNA-mediated depletion of KLF5 in the Calu-3 lung
epithelial cell line identified significant enrichment of genes encoding chemokines and …
maintaining key biological properties of the human airway epithelium. However, detailed
knowledge of the contributing factors is incomplete. Here we characterize the role of Krüppel-
like factor 5 (KLF5), in controlling essential pathways of epithelial cell identity and function in
the human lung. RNA-seq following siRNA-mediated depletion of KLF5 in the Calu-3 lung
epithelial cell line identified significant enrichment of genes encoding chemokines and …