Which therapeutic strategy will achieve a cure for HIV-1?
AR Cillo, JW Mellors - Current opinion in virology, 2016 - Elsevier
Highlights•Eradication, functional, and hybrid cures for HIV-1 are under investigation.•'Kick
and kill'has been the most intensively studied curative strategy to date.•HIV-1 latency
reversing agents have increased cellular HIV-1 RNA in vivo.•Whether latency reversing
agents are safe and can deplete the reservoir is unknown.•Boosting immunologic control of
HIV-1 should be pursued as part of a hybrid cure.Strategies to achieve a cure for HIV-1
infection can be broadly classified into three categories: eradication cure (elimination of all …
and kill'has been the most intensively studied curative strategy to date.•HIV-1 latency
reversing agents have increased cellular HIV-1 RNA in vivo.•Whether latency reversing
agents are safe and can deplete the reservoir is unknown.•Boosting immunologic control of
HIV-1 should be pursued as part of a hybrid cure.Strategies to achieve a cure for HIV-1
infection can be broadly classified into three categories: eradication cure (elimination of all …