Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis
JT Lin, EA Stein, MT Wong, KJ Kalpathy, LL Su… - Clinical …, 2012 - Elsevier
The signaling pathways utilized by naïve and experienced effector CD4 T cells during
activation and proliferation were evaluated. While inhibition of either mTOR or MAPK alone
was able to inhibit naïve T cell proliferation, both mTOR and MAPK (ERK) pathway inhibition
was required to efficiently block experienced, effector CD4 T cell proliferation. This was
demonstrated both in vitro, and in vivo by treating mice with collagen-induced arthritis using
mTOR and/or ERK inhibitors. The combination of mTOR and ERK inhibition prevented or …
activation and proliferation were evaluated. While inhibition of either mTOR or MAPK alone
was able to inhibit naïve T cell proliferation, both mTOR and MAPK (ERK) pathway inhibition
was required to efficiently block experienced, effector CD4 T cell proliferation. This was
demonstrated both in vitro, and in vivo by treating mice with collagen-induced arthritis using
mTOR and/or ERK inhibitors. The combination of mTOR and ERK inhibition prevented or …
