Novel pharmacological TRPC inhibitors block hypoxia-induced vasoconstriction
N Urban, K Hill, L Wang, WM Kuebler, M Schaefer - Cell calcium, 2012 - Elsevier
The Ca2+-permeable, nonselective cation channel TRPC6 is gated via phospholipase C-
activating receptors and has recently been implicated in hypoxia-induced pulmonary
vasoconstriction (HPV), idiopathic pulmonary hypertension and focal segmental
glomerulosclerosis (FSGS). Therefore, TRPC6 is a promising target for pharmacological
interference. To identify and develop TRPC6-blocking compounds, we screened the
Chembionet library, a collection of 16,671 chemically diverse drug-like compounds, for …
activating receptors and has recently been implicated in hypoxia-induced pulmonary
vasoconstriction (HPV), idiopathic pulmonary hypertension and focal segmental
glomerulosclerosis (FSGS). Therefore, TRPC6 is a promising target for pharmacological
interference. To identify and develop TRPC6-blocking compounds, we screened the
Chembionet library, a collection of 16,671 chemically diverse drug-like compounds, for …
