Hypertrophy of the heart: a new therapeutic target?

N Frey, HA Katus, EN Olson, JA Hill - Circulation, 2004 - Am Heart Assoc
N Frey, HA Katus, EN Olson, JA Hill
Circulation, 2004Am Heart Assoc
Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent
progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing
hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling
pathways that hold promise as potential targets for therapeutic intervention. We also
summarize observations from animal models and clinical trials that suggest benefit from an …
Recent studies call into question the necessity of hypertrophic growth of the heart as a “compensatory” response to hemodynamic stress. These findings, coupled with recent progress in dissecting the molecular bases of hypertrophy, raise the prospect of suppressing hypertrophy without provoking circulatory insufficiency. In this article, we focus on signaling pathways that hold promise as potential targets for therapeutic intervention. We also summarize observations from animal models and clinical trials that suggest benefit from an antihypertrophic strategy.
Am Heart Assoc