[HTML][HTML] IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques
Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been
attributed to persistent immune dysfunction, in part due to abnormalities at the
gastrointestinal barrier. In particular, the poor reconstitution of gastrointestinal Th17 cells
correlates with residual translocation of dysbiotic, immunostimulatory microflora across a
compromised intestinal epithelial barrier. We have previously demonstrated that oral
probiotics promote increased intestinal CD4+ T-cell reconstitution during ARV treatment in a …
attributed to persistent immune dysfunction, in part due to abnormalities at the
gastrointestinal barrier. In particular, the poor reconstitution of gastrointestinal Th17 cells
correlates with residual translocation of dysbiotic, immunostimulatory microflora across a
compromised intestinal epithelial barrier. We have previously demonstrated that oral
probiotics promote increased intestinal CD4+ T-cell reconstitution during ARV treatment in a …