[HTML][HTML] CCR6− regulatory T cells blunt the restoration of gut Th17 cells along the CCR6–CCL20 axis in treated HIV-1-infected individuals
C Loiseau, M Requena, M Mavigner, M Cazabat… - Mucosal …, 2016 - Elsevier
The gut CD4+ T cells, particularly the T helper type 17 (Th17) subset, are not completely
restored in most HIV-1-infected individuals despite combined antiretroviral therapy, when
initiated at the chronic phase of infection. We show here that the CCR6–CCL20 chemotactic
axis is altered, with reduced CCL20 production by small intestine epithelial cells in treated
HIV-1-infected individuals. This leads to impaired CCR6+ CD4+ T-cell homing, particularly
Th17 cells, to the small intestine mucosa. In contrast, the frequency of gut FoxP3+ T …
restored in most HIV-1-infected individuals despite combined antiretroviral therapy, when
initiated at the chronic phase of infection. We show here that the CCR6–CCL20 chemotactic
axis is altered, with reduced CCL20 production by small intestine epithelial cells in treated
HIV-1-infected individuals. This leads to impaired CCR6+ CD4+ T-cell homing, particularly
Th17 cells, to the small intestine mucosa. In contrast, the frequency of gut FoxP3+ T …
