[HTML][HTML] Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional HIV …

M Macal, S Sankaran, TW Chun, E Reay, J Flamm… - Mucosal …, 2008 - Elsevier
Human immunodeficiency virus (HIV) infection leads to severe CD4+ T-cell depletion in gut-
associated lymphoid tissue (GALT) that persists despite the initiation of highly active
antiretroviral therapy (HAART). It is not known whether restoration of gut mucosal CD4+ T
cells and their functions is feasible during therapy and how that relates to immune correlates
and viral reservoirs. Intestinal biopsies and peripheral blood samples from HIV-infected
patients who were either HAART naive or on long-term HAART were evaluated. Our data …