[HTML][HTML] Preferential M2 macrophages contribute to fibrosis in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease
S Furukawa, M Moriyama, A Tanaka, T Maehara… - Clinical …, 2015 - Elsevier
IgG4-related dacryoadenitis and sialoadenitis (IgG4-DS) is characterized by bilateral
swelling of glandular tissues with extensive fibrosis, and is immunologically considered a
Th2-predominant disease. Recent studies reported that alternatively activated (M2)
macrophages enhanced Th2 immune responses and fibrosis by production of pro-fibrotic
factors (IL-10, IL-13 and CCL18). Therefore, we examined the association between M2
macrophages and fibrosis in submandibular glands from 7 patients with IgG4-DS, 10 …
swelling of glandular tissues with extensive fibrosis, and is immunologically considered a
Th2-predominant disease. Recent studies reported that alternatively activated (M2)
macrophages enhanced Th2 immune responses and fibrosis by production of pro-fibrotic
factors (IL-10, IL-13 and CCL18). Therefore, we examined the association between M2
macrophages and fibrosis in submandibular glands from 7 patients with IgG4-DS, 10 …