Functional role of protease activated receptors in vascular biology
MA Alberelli, E De Candia - Vascular pharmacology, 2014 - Elsevier
Protease activated receptors (PARs) are a small family of G protein-coupled receptors
(GPCR) mediating the cellular effects of some proteases of the coagulation system, such as
thrombin, or other proteases, such as trypsin or metalloproteinase 1. As the prototype of
PARs, PAR1 is a seven transmembrane GPCR that, upon cleavage by thrombin, unmasks a
new amino-terminus able to bind intramolecularly to PAR1 itself thus inducing signaling. In
the vascular system, thrombin and other proteases of the coagulation-fibrinolysis system …
(GPCR) mediating the cellular effects of some proteases of the coagulation system, such as
thrombin, or other proteases, such as trypsin or metalloproteinase 1. As the prototype of
PARs, PAR1 is a seven transmembrane GPCR that, upon cleavage by thrombin, unmasks a
new amino-terminus able to bind intramolecularly to PAR1 itself thus inducing signaling. In
the vascular system, thrombin and other proteases of the coagulation-fibrinolysis system …