Type I interferons in viral control and immune regulation
JR Teijaro - Current opinion in virology, 2016 - Elsevier
Highlights•IFN-I signaling has recently been shown to contribute to viral immune
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple
species.•Blocking IFN-I signaling reduces immune system activation, regulatory molecule
expression.•Inhibiting IFN-I signaling promotes hastened control of persistent LCMV
infection.•Targeting IFN-I signaling during viral infection may treat a range of viral
diseases.Type 1 interferons (IFN-I) exert pleiotropic biological effects during viral infections …
pathologies.•Elevated IFN-I signatures are found in persistent virus infections in multiple
species.•Blocking IFN-I signaling reduces immune system activation, regulatory molecule
expression.•Inhibiting IFN-I signaling promotes hastened control of persistent LCMV
infection.•Targeting IFN-I signaling during viral infection may treat a range of viral
diseases.Type 1 interferons (IFN-I) exert pleiotropic biological effects during viral infections …
