[HTML][HTML] Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma
J Li, S Zhu, J Tong, H Hao, J Yang, Z Liu, Y Wang - Neuroreport, 2016 - journals.lww.com
Reprogrammed glucose metabolism is an emerging hallmark of cancer cells, which show a
unique metabolic phenotype known as the Warburg effect. Lactate dehydrogenase A
(LDHA), a key enzyme in the glycolytic process, executes the final step by conversion of
lactate into pyruvate. However, little is known about the roles of LDHA in human
glioblastoma (GBM). In this study, we aimed to determine the effects of LDHA and elucidate
related underlying mechanisms. Data derived from Oncomine database showed that LDHA …
unique metabolic phenotype known as the Warburg effect. Lactate dehydrogenase A
(LDHA), a key enzyme in the glycolytic process, executes the final step by conversion of
lactate into pyruvate. However, little is known about the roles of LDHA in human
glioblastoma (GBM). In this study, we aimed to determine the effects of LDHA and elucidate
related underlying mechanisms. Data derived from Oncomine database showed that LDHA …